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Psychosis, Schizophrenia, or Autoimmune Brain Inflammation—New Hope for Some

Psychosis, Schizophrenia, or Autoimmune Brain Inflammation—New Hope for Some

One of the most distressing things a person can go through is a break in their touch with reality—psychosis—whether in themselves or in a loved one. Psychosis is a term for no longer being able to tell what is real from what is not. The various types of psychotic symptoms include:

  • Hallucinations: These are disturbances in perception—perceiving sensory signals that are not coming from the world around us. The most common is auditory hallucination, hearing things without actual sound waves impacting the ear drums, but people can also see, smell, feel, and taste things that are not coming from their environment.
  • Delusions: These are fixed false beliefs—believing things that are objectively contrary to reality; delusional beliefs are not amenable to being changed with evidence and facts.
  • Disorganization of thought and speech: The inability to maintain a clear train of thought; jumping from topic to topic in a nonsensical way.
  • Disorganization of behavior: Gross irrational and chaotic behavior.
  • Catatonia: A severe and abnormal response to people and the environment, such as mutism, echoing sounds repeatedly, copying other’s movements constantly, rigidly holding positions for long periods of time, failure to respond to environmental stimuli, and other symptoms.
  • Severe loss of normal emotional connection: Severe emotional flatness; loss of motivation, disengagement, and isolation.

It has been long understood that psychotic problems are a result of something going wrong with normal brain function. The only exception are shared delusions, when people come to believe something that is false and are resistant to evidence that would expose the falsehood. Shared or group delusions come from social and relational pressures and not brain dysfunction. So, delusions can occur from both brain dysfunction and from social and relational pressures and stresses.

Historically, when a person presented with the various symptoms listed above, they were recognized as having a break from reality and diagnosed with psychosis. If the symptoms persisted over time, they were often diagnosed with schizophrenia.

The exact causes of schizophrenia are still poorly understood, but it is believed to have multiple causes related to brain development, structure, and function. Genetics play a role, increasing vulnerability, but genes do not tell the entire story. Intrauterine environment, toxic exposures, infections, nutritional deficiencies, and environmental stressors all impact the developing brain and can alter normal cellular development, support systems, and connectivity and, thereby, contribute to the development of psychosis later in life. The point is that every person diagnosed with schizophrenia does not have the exact same brain problem; they share a cluster of symptoms that are used to diagnose schizophrenia. But it is currently believed that there are many different underlying contributing factors and brain changes that lead to these symptoms.

 

New Discoveries

What is interesting is that recently, a condition has been discovered that shares the symptoms of schizophrenia and historically would have been diagnosed as schizophrenia but, in fact, is an autoimmune inflammation of the brain. In other words, the body has made antibodies that are acting inappropriately upon certain brain receptors (NMDA) and causing the symptoms of psychosis.

Recently I read an article entitled “Is it psychosis, or an autoimmune encephalitis?” in which the differences between psychosis and this brain inflammatory condition were described. This is important and exciting because the presentations of both these conditions are nearly identical while the underlying causes are quite distinct and the treatments are necessarily different, with the autoimmune condition having a higher likelihood of resolution with appropriate treatment.

The symptoms of the autoimmune brain condition are some combination of the symptoms of psychosis listed above. A person with the autoimmune encephalitis may become disorganized, stop going to classes or work, socially isolate, stop attending to personal hygiene, talk to self, accuse people of being against them, believe others are out to get them, may become catatonic and withdrawn and become mute, or posture in strange ways. Their thoughts may be disorganized; they may be animated or agitated. The point is, there is a marked dysfunctional change from their normal behavior that is recognized by family and friends.

Clues that this may be autoimmune rather than schizophrenia include:

  • Quick onset in less than three months. If such changes have occurred gradually over years in a person who was odd, socially withdrawn, and peculiar since childhood, then it is more likely schizophrenia. But if the person experiences a fairly sudden and acute change in function, then the possibility of autoimmune encephalitis must be considered.
  • Recent history of infection, especially viral infection, prior to the onset of the dysfunction is a red flag warranting workup for autoimmune encephalitis. The underlying problem is that something (in this case, the viral infection) triggers the body’s immune system to make antibodies that attack the NMDA receptors in the brain, thereby causing the psychosis. Thus, a history of fever, malaise, headache, nausea, diarrhea, etc., prior to the onset of symptoms is a signal warranting investigation for an autoimmune cause.
  • Seizures within one year of the onset of the psychotic symptoms. These seizures are usually not the full-body seizures with loss of consciousness, but deep brain seizures that cause moments of confusion, staring off into space, or no symptoms at all and only show electrical slowing on an electroencephalogram (EEG). But seizures of any kind during the first year suggests an autoimmune problem.
  • A recent history of cancer or any abnormality of the ovaries suggests autoimmune encephalitis rather than schizophrenia. The cancer or ovarian problem, in this case, trigger the immune system to make the antibodies that attack the NMDA receptors.
  • A prior history of herpes simplex virus (HSV) encephalitis increases the risk of autoimmune encephalitis and, thus, any person presenting with psychosis who has a history of prior HSV encephalitis should be evaluated for an autoimmune cause of their psychosis. Again, the connection is that the prior herpes viral infection triggered the body to make antibodies that are now attacking the brain.
  • Any symptoms suggestive of a neurological problem, such as a stiff neck, severe headache, neck pain, etc., should raise concerns and justify an autoimmune workup.
  • Presenting with short-term memory loss may indicate an autoimmune cause to the new psychosis.
  • Changes and instability in normal vital signs, such as a racing heart, blood pressure that changes rapidly, and light headedness when standing, are indicators of an underlying autoimmune problem.

If someone you know is suffering with such symptoms, please bring up this possibility to their doctor as autoimmune encephalitis presenting as a psychotic disorder is a newly discovered insight and may not be considered by your loved-one’s doctor. The treatment for autoimmune encephalitis is quite different than that for schizophrenia, with a much higher likelihood of a good outcome.

 

 

 

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Testimony 33

I was invited over a friend’s house to see the “God and Your Brain” seminar today. I became [a christian] 36 years ago at the age of 19, but have struggled with the concept of God taking His ‘pound of flesh’ out on His Son to be appeased. Wow. Your seminar has been an incredible revelation and breath of reason and fresh air! I have your book, “The God Shaped Brain,” and it is SO eye opening. Finally, after 36 years enlightenment has come! Praise the Good Lord! What can I say, but that the Real Gospel is truly “Good News!” Thank you for your efforts in giving the Gospel a clear sound!

Paul C.,  Springfield, MA, USA

 

Testimony 4

I’m a youth leader in South Africa. We as a youth group are currently using a lot of the material on the Come and Reason site. Since we’ve started using the material, our youth group has grown.

R. V. N., South Africa

 

Testimony 28

I have been following your Bible study class for about a year now. I must say I am impressed with how your ministry has grown. I took it upon myself to listen to all your lesson podcasts from the past and they have both enriched me physically, mentally, emotionally and spiritually. I have learnt a lot from this class. I have also noticed how the class has grown in spiritual strength. One of the things that benefited me is that now I am not afraid of God. I use to be, but now it has melted away. The second thing is that you helped me to have a real life relationship with God. Now He is my friend that was always there and I love having him with me all the time. Thirdly, because of this class, it inspired me to take over and lead a class. I have called it “Let Us Reason Together,” adapting your inquisitive style and creating a class of free thinkers.

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Testimony 55

I was born [into the church], then I left it for many years. 10 years ago, I came back, but I could not take the hypocrisy and the lack of answers to the missing pieces. I struggled, but I did not abandon my commitment to know the truth. God is leading me to the simple understanding of his relevance and I am relearning what the church taught me as a youth… that he loves me, that he has led me to a knowledge of him such as I have never known. He is using Dr. Jennings to connect the dots that are now so apparent and hiding in plain sight!

Dean P., Arlington, TX, USA

 

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Testimony 70

I have been watching you for many years and have learned to love God with all my heart. I was raised by a loving Christian mother that had been lied to about who God really was, so our religious upbringing was hell fire and damnation. As soon as I was old enough and moved out, I not only left the church, I ran as fast as I could to get away from it. Sad to say, it wasn’t until the past couple of years that I learned and understand who my Father really is and how much He loves me. I understand God’s Design Laws (which make sense) and when I’m teaching my church Bible study class, I’m able to really put to use the things I’ve been learning and Holy Spirit is leading. Thank you for introducing me to my Father of true, pure love. Everyday with Him is new and exciting. One thing that breaks my heart is that I didn’t know Him sooner. God Bless you and your ministry!

Judy Phelps, Reno, NV, USA

Testimony 12

I have been really blessed reading your response to the various questions on your site.

K.C., OH, USA

 

Testimony 60

Just watched watched lesson 10 in the 1st quarter 2021 bible study classs on Isaiah. I want to thank you for your intellectual spirituality; it’s not an oxymoron! From the point of view of a teacher I also enjoy seeing how much personal pleasure you clearly take in not just tasting, but feasting on God’s word – it reminds me of Jeremiah not being able to hold it in! It makes me smile that your cup is so full and overflowing that you make it to Tuesday’s lesson (on a good day). It just goes to show the richness of God’s Word.

God bless the Come and Reason Team from our church here in Great Britain.

Andrew H., Great Britain

 

Testimony 37

Hearing Dr. Jennings’ presentations in person came at a pivotal moment in my spiritual journey that began about nine months ago, when the fault lines inherent in my belief system began to crack under questions that most reasonable people end up asking about God and His nature. These were questions I couldn’t find answers to, and they shook my faith. I was unable let it go any longer and be satisfied. My Christian experience became distant. I was afraid; the fear in me rose like thorns, pushing me away from Jesus. And then someone heard my questions and introduced me to this ministry, and my life has totally changed.

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Anthony L., CA, USA

 

Testimony 62

I would like to express my thanks to the C&R team for creating a platform from which people can learn to trust in God and grow. My life is a witness to the effectiveness of this ministry. Without believing the truth about God as you have shown, I don’t know what my life would be like. I had given up on God helping me with certain sins – it was all useless. Given that the scripture is clear and God is so good, how could I have betrayed him so many times? I was a yo-yo christian; spinning up and down. My faith and enthusiasm was driven by discoveries/threats that prophecy is about to be fulfilled. But when I watched your “Healing the Mind” seminar, it was like a light finally went on. I could see God had no plan to hurt me, the danger came from sin, and that He is working to protect me and strengthen me. Thank you for allowing God to use you. The message God gave C&R saved my life!

Antony N. – Hobart, Australia

 

Testimony 20

I just wanted to personally thank you for your teachings and insight into scripture. I came across your website via my cousin who suggested I look into “Healing the Mind” information. My youngest daughter has been struggling over the last couple of years and it all came to a head this spring. When I started listening to the “Healing the Mind” lectures my own life began to be transformed. I began sharing with all my daughters the concepts you laid out so clearly. I ordered your book and soaked it up. I just want to say “Thank You!” My walk with the Lord has been refreshed and renewed. Your obedience to the Lord is a blessing to so many.

R. K., Anderson, SC, USA

 

Testimony 66

I am incredibly grateful for the transformative impact you’ve had on my life, and words cannot fully express my appreciation. Over the years, I have been an avid listener and follower of C&R and extend my heartfelt thanks for creating the C&R mobile app. It has allowed me to immerse myself in your lessons repeatedly, enabling me to grasp the profound significance about the Character of God, Design Law, the protocols for life, the reasons behind the current chaos, and Christ’s mission to restore everything. They have deeply touched me. Having studied with various churches, I came away with the perception that God is no different from the deities of ancient Greek or Roman mythology—demanding sacrifices and taking pleasure in bloodshed. Thanks to your transformative teachings, I have experienced a profound awakening to the true nature of God and the immense power of His love. It is truly a remarkable and liberating sensation to finally grasp the truth and embrace the empowering nature of God’s laws. My self-perception has become brighter and more infused with love. My journey of growth continues on a daily basis.

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Testimony 49

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R. N., MT, USA

 

Testimony 19

I truly believe that to know who God really is the first step to understand ourselves in a balanced and kind way, so the healing can take place. Your approach really makes sense – Thank you for your ministry!

A.M., Pittsburg, PA, USA