Call Us: 423 661-4734 | Email: requests@comeandreason.com      
Psychosis, Schizophrenia, or Autoimmune Brain Inflammation—New Hope for Some

Psychosis, Schizophrenia, or Autoimmune Brain Inflammation—New Hope for Some

One of the most distressing things a person can go through is a break in their touch with reality—psychosis—whether in themselves or in a loved one. Psychosis is a term for no longer being able to tell what is real from what is not. The various types of psychotic symptoms include:

  • Hallucinations: These are disturbances in perception—perceiving sensory signals that are not coming from the world around us. The most common is auditory hallucination, hearing things without actual sound waves impacting the ear drums, but people can also see, smell, feel, and taste things that are not coming from their environment.
  • Delusions: These are fixed false beliefs—believing things that are objectively contrary to reality; delusional beliefs are not amenable to being changed with evidence and facts.
  • Disorganization of thought and speech: The inability to maintain a clear train of thought; jumping from topic to topic in a nonsensical way.
  • Disorganization of behavior: Gross irrational and chaotic behavior.
  • Catatonia: A severe and abnormal response to people and the environment, such as mutism, echoing sounds repeatedly, copying other’s movements constantly, rigidly holding positions for long periods of time, failure to respond to environmental stimuli, and other symptoms.
  • Severe loss of normal emotional connection: Severe emotional flatness; loss of motivation, disengagement, and isolation.

It has been long understood that psychotic problems are a result of something going wrong with normal brain function. The only exception are shared delusions, when people come to believe something that is false and are resistant to evidence that would expose the falsehood. Shared or group delusions come from social and relational pressures and not brain dysfunction. So, delusions can occur from both brain dysfunction and from social and relational pressures and stresses.

Historically, when a person presented with the various symptoms listed above, they were recognized as having a break from reality and diagnosed with psychosis. If the symptoms persisted over time, they were often diagnosed with schizophrenia.

The exact causes of schizophrenia are still poorly understood, but it is believed to have multiple causes related to brain development, structure, and function. Genetics play a role, increasing vulnerability, but genes do not tell the entire story. Intrauterine environment, toxic exposures, infections, nutritional deficiencies, and environmental stressors all impact the developing brain and can alter normal cellular development, support systems, and connectivity and, thereby, contribute to the development of psychosis later in life. The point is that every person diagnosed with schizophrenia does not have the exact same brain problem; they share a cluster of symptoms that are used to diagnose schizophrenia. But it is currently believed that there are many different underlying contributing factors and brain changes that lead to these symptoms.

 

New Discoveries

What is interesting is that recently, a condition has been discovered that shares the symptoms of schizophrenia and historically would have been diagnosed as schizophrenia but, in fact, is an autoimmune inflammation of the brain. In other words, the body has made antibodies that are acting inappropriately upon certain brain receptors (NMDA) and causing the symptoms of psychosis.

Recently I read an article entitled “Is it psychosis, or an autoimmune encephalitis?” in which the differences between psychosis and this brain inflammatory condition were described. This is important and exciting because the presentations of both these conditions are nearly identical while the underlying causes are quite distinct and the treatments are necessarily different, with the autoimmune condition having a higher likelihood of resolution with appropriate treatment.

The symptoms of the autoimmune brain condition are some combination of the symptoms of psychosis listed above. A person with the autoimmune encephalitis may become disorganized, stop going to classes or work, socially isolate, stop attending to personal hygiene, talk to self, accuse people of being against them, believe others are out to get them, may become catatonic and withdrawn and become mute, or posture in strange ways. Their thoughts may be disorganized; they may be animated or agitated. The point is, there is a marked dysfunctional change from their normal behavior that is recognized by family and friends.

Clues that this may be autoimmune rather than schizophrenia include:

  • Quick onset in less than three months. If such changes have occurred gradually over years in a person who was odd, socially withdrawn, and peculiar since childhood, then it is more likely schizophrenia. But if the person experiences a fairly sudden and acute change in function, then the possibility of autoimmune encephalitis must be considered.
  • Recent history of infection, especially viral infection, prior to the onset of the dysfunction is a red flag warranting workup for autoimmune encephalitis. The underlying problem is that something (in this case, the viral infection) triggers the body’s immune system to make antibodies that attack the NMDA receptors in the brain, thereby causing the psychosis. Thus, a history of fever, malaise, headache, nausea, diarrhea, etc., prior to the onset of symptoms is a signal warranting investigation for an autoimmune cause.
  • Seizures within one year of the onset of the psychotic symptoms. These seizures are usually not the full-body seizures with loss of consciousness, but deep brain seizures that cause moments of confusion, staring off into space, or no symptoms at all and only show electrical slowing on an electroencephalogram (EEG). But seizures of any kind during the first year suggests an autoimmune problem.
  • A recent history of cancer or any abnormality of the ovaries suggests autoimmune encephalitis rather than schizophrenia. The cancer or ovarian problem, in this case, trigger the immune system to make the antibodies that attack the NMDA receptors.
  • A prior history of herpes simplex virus (HSV) encephalitis increases the risk of autoimmune encephalitis and, thus, any person presenting with psychosis who has a history of prior HSV encephalitis should be evaluated for an autoimmune cause of their psychosis. Again, the connection is that the prior herpes viral infection triggered the body to make antibodies that are now attacking the brain.
  • Any symptoms suggestive of a neurological problem, such as a stiff neck, severe headache, neck pain, etc., should raise concerns and justify an autoimmune workup.
  • Presenting with short-term memory loss may indicate an autoimmune cause to the new psychosis.
  • Changes and instability in normal vital signs, such as a racing heart, blood pressure that changes rapidly, and light headedness when standing, are indicators of an underlying autoimmune problem.

If someone you know is suffering with such symptoms, please bring up this possibility to their doctor as autoimmune encephalitis presenting as a psychotic disorder is a newly discovered insight and may not be considered by your loved-one’s doctor. The treatment for autoimmune encephalitis is quite different than that for schizophrenia, with a much higher likelihood of a good outcome.

 

 

 

Email me the blog whenever a new one is published.

Donate online, securely via PayPal using your credit or debit card (no PayPal account needed, unless you want to set up a monthly, recurring payment).


cancel recurring payment

 

Want to use zelle instead?
See how on our
Support and Donations page.

Upcoming Events

calendar

Testimonial Post Slider

Testimony 46

Over the past couple of years God has been expanding my view of Himself and His character. Along my approximately 40-year journey, I have often had questions, but was hesitant to voice these and step outside the traditionally accepted thinking, for fear of admitting that I may in fact be eternally lost. In the recesses of my thinking has been the thought – if one blindly accepts (which is widely regarded as “real faith”) and does not question, is this really ‘truth?’ I often find it challenging to grapple with very theological ‘speak,’ but Dr. Jennings has a real gift of explaining spiritual concepts with clear practical examples. The weekly discussions are growing my Christian experience and slowly changing my view of how to live as a child of God in today’s complex world. Finally the whole Old Testament sanctuary teaching moved in my mind from fantasy to reality!

Beverly S., South Africa

 

Testimony 10

I personally download and listen to each of Come And Reason Ministries Bible study class lessons and PDF study notes to use when teaching my class. Really appreciate the class especially when Dr. Jennings is teaching. Thank God there are persons like him doing His work and traveling to share His beliefs.

B. L.M., North Plains, OR, USA

 

Testimony 51

I Love This Ministry!!!!!!! I see first hand how this message is desperately needed, how erroneous beliefs about God and His Character negatively affect humanity at every level. I thank God for your ministry, as I was searching on my own and was discovering some of your same beliefs and was blown away when I found your ministry. I know you hear it all the time, but it is truly life changing. May God continue to reveal His Will to you and Bless you!

Eric S., Sanford, FL, USA

 

Testimony 58

I have been watching your videos in The Power of Love seminar and I must say these have liberated me and have improved my relationship with the Lord. I am no longer terrified of him as I was before following your teachings.

Thando N., South Africa

 

Testimony 21

I am absolutly on fire with the message at Come and Reason! I can’t get enough! I’ve read your book, blog, and articles. I’ve listened to your Bible study podcasts, your radio show, and your series – all excellent! It wasn’t until the past couple of years that I have I like I’m becoming “healthy,” with more to share with others than just beasts and commandments! I used to be a Bible worker and preached when the pastors were gone until I had had enough. I didnt realize at the time what the problem was, but i know now… the message wasn’t properly focused. Now my flame is rekindled. All of your little examples are so perfect in explaining something “complicated” and making it easily understood! Now I’m trying to shape it into a life changing evangelistic series! Thank you!

M.T., USA

 

Testimony 20

I just wanted to personally thank you for your teachings and insight into scripture. I came across your website via my cousin who suggested I look into “Healing the Mind” information. My youngest daughter has been struggling over the last couple of years and it all came to a head this spring. When I started listening to the “Healing the Mind” lectures my own life began to be transformed. I began sharing with all my daughters the concepts you laid out so clearly. I ordered your book and soaked it up. I just want to say “Thank You!” My walk with the Lord has been refreshed and renewed. Your obedience to the Lord is a blessing to so many.

R. K., Anderson, SC, USA

 

Testimony 65

I have been tuning into your weekly study classes for a while now and wanted express my appreciation for the teachings that ha been a huge blessing in opening up the true message of the word. Viewing scripture under an imposed law theory always, without fail, raised more questions, concerns, and conflicting scripture interpretations that were discouraging at the very least. Looking at scripture through the design law lens has brought more truth to light for me personally and an understanding of our Heavenly Father that places Him “above all others,” where I am now more than thrilled to witness and serve Him.  I “stumbled” across this ministry a year or so ago and would only watch a few minutes at a time. But the more I listened and the longer I paid attention, the more my spiritual eyes were opened to the ever present truths of scripture. The comprehension of the great controversy and it’s origin by the lies perpetrated and perpetuated throughout the Bible on the attack of God’s character and government is truly priceless. Keep up the Good Work! Your servanthood is desperately needed in such a time as this!

Jeff D., Reading, MA, USA

 

Testimony 4

I’m a youth leader in South Africa. We as a youth group are currently using a lot of the material on the Come and Reason site. Since we’ve started using the material, our youth group has grown.

R. V. N., South Africa

 

Testimony 48

I just want to tell you how blessed I have been reading “The Remedy!” It has become a daily part of my devotional relationship with God. In it I have found a God of love and a God that loves me! The bible has come alive for me! It is the first time that I can say that I have felt hope fill my heart as I have read God’s word. This is good news I can share! Thank you, Dr Jennings! Thank you for your heart for others. I can’t put into words how this has set me free! It has strengthened my trust and love for God.

Jason H.

 

Testimony 7

Ok, so last night I listened to “The Law of Liberty” and “How to Achieve Victory: Freedom, Truth and Spirtual Warfare.” These are both MY ABSOLUTE FAVORITES so far! The logic is just soooooo beautiful. I had to re-listen to them a couple of times. I just want to EXPLODE! (<< we assume with joy and happiness)

N. B., Canada

 

Testimony 59

I’m a native Ghanan, but am currently in France for my master’s degree. Prior to this, during my final years at undergraduate studies in Ghana, I was introduced to your ministry and I’ve been immensely blessed by what you share, especially about the Design and Imposed Laws. God richly bless you for that.

One of the first things I did when I arrived in France was to buy all four of your books. They not only helped me, but those I shared them with. I shared the message with an atheist student and I marveled at how God worked mightily in his life. Today this person shares the Love of God with others and debunks theories of who God is not. I want to share what you present in your “Heavenly Sanctuary and Investigative Judgment” pamphlet, because the message brought rest to my soul and I live today as a healthy person.

God bless you so much and your ministry.

Michael A., Ghana

 

Testimony 67

I was introduced to Come And Reason by a friend of my mother-in-law, who gave me several CD’s of Dr. Jennings. The clarity of the message and recognition that God’s is a God of love was so clear, advancing beyond Dr. Maxwell’s message. However, grappled with Maxwell saying God used emergency measures for the fallen world. Now after several years of being a regular listener of the Come And Reasoning bible study class and attending Jennings’ meetings in Dallas/Fort Worth, TX, things are becoming clearer for me. Design law versus imposed law has added so much to my personal understanding of theology. This message has really impacted my work in counseling so many people miserable because they are searching for and trusting human governments to create order and peace or believing in a God who says love Me or I will kill you. I am grateful that I have an alternative view to offer my clients that makes sense. I teach a bible study class on a semi-regular basis and I value the materials that Come And Reason so freely offers to aid me in presenting this vital message. Thank you for continuing to provide advancement in our very limited understanding of a Infinite God that is rational and believable.

Dr. Roger D, Arlington, TX, USA

 

Testimony 63

I’ve been very blessed by “The God Shaped Brain” and this ministry, through video and podcast, over the last few years. It’s truly opened up my eyes more to the truth about God and the importance of that truth in the present world. The message is so inviting, freeing and enlightening and MORE people need to know about it. I believe it is the last message that can truly, not only prepare a people for salvation and translation, but vindicate the character of God.

Michael V., Yonkers, NY, USA

 

Testimony 22

I have found your Bible study class lectures to be very inspiring and useful as I prepare to teach class every other week. I subscribe to the podcast and download your notes on the weeks I teach. The audio and notes are such a great help in preparing. My own understanding of God’s character has grown as I teach the class. Commendations on the thought-provoking and well-prepared material Come and Reason provides. Personally, I get excited by the tie you make between the spiritual and mental/physical domains.

A.A. Corrales, NM, USA

 

Testimony 1

Thank you! I love listening to the Come And Reason Ministries Bible study classes and am using some of your notes to get the lessons together that I will be teaching. You always have such good quotes and Bible texts and pull things together to make good sense.

T. C., IN, USA