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Psychosis, Schizophrenia, or Autoimmune Brain Inflammation—New Hope for Some

Psychosis, Schizophrenia, or Autoimmune Brain Inflammation—New Hope for Some

One of the most distressing things a person can go through is a break in their touch with reality—psychosis—whether in themselves or in a loved one. Psychosis is a term for no longer being able to tell what is real from what is not. The various types of psychotic symptoms include:

  • Hallucinations: These are disturbances in perception—perceiving sensory signals that are not coming from the world around us. The most common is auditory hallucination, hearing things without actual sound waves impacting the ear drums, but people can also see, smell, feel, and taste things that are not coming from their environment.
  • Delusions: These are fixed false beliefs—believing things that are objectively contrary to reality; delusional beliefs are not amenable to being changed with evidence and facts.
  • Disorganization of thought and speech: The inability to maintain a clear train of thought; jumping from topic to topic in a nonsensical way.
  • Disorganization of behavior: Gross irrational and chaotic behavior.
  • Catatonia: A severe and abnormal response to people and the environment, such as mutism, echoing sounds repeatedly, copying other’s movements constantly, rigidly holding positions for long periods of time, failure to respond to environmental stimuli, and other symptoms.
  • Severe loss of normal emotional connection: Severe emotional flatness; loss of motivation, disengagement, and isolation.

It has been long understood that psychotic problems are a result of something going wrong with normal brain function. The only exception are shared delusions, when people come to believe something that is false and are resistant to evidence that would expose the falsehood. Shared or group delusions come from social and relational pressures and not brain dysfunction. So, delusions can occur from both brain dysfunction and from social and relational pressures and stresses.

Historically, when a person presented with the various symptoms listed above, they were recognized as having a break from reality and diagnosed with psychosis. If the symptoms persisted over time, they were often diagnosed with schizophrenia.

The exact causes of schizophrenia are still poorly understood, but it is believed to have multiple causes related to brain development, structure, and function. Genetics play a role, increasing vulnerability, but genes do not tell the entire story. Intrauterine environment, toxic exposures, infections, nutritional deficiencies, and environmental stressors all impact the developing brain and can alter normal cellular development, support systems, and connectivity and, thereby, contribute to the development of psychosis later in life. The point is that every person diagnosed with schizophrenia does not have the exact same brain problem; they share a cluster of symptoms that are used to diagnose schizophrenia. But it is currently believed that there are many different underlying contributing factors and brain changes that lead to these symptoms.

 

New Discoveries

What is interesting is that recently, a condition has been discovered that shares the symptoms of schizophrenia and historically would have been diagnosed as schizophrenia but, in fact, is an autoimmune inflammation of the brain. In other words, the body has made antibodies that are acting inappropriately upon certain brain receptors (NMDA) and causing the symptoms of psychosis.

Recently I read an article entitled “Is it psychosis, or an autoimmune encephalitis?” in which the differences between psychosis and this brain inflammatory condition were described. This is important and exciting because the presentations of both these conditions are nearly identical while the underlying causes are quite distinct and the treatments are necessarily different, with the autoimmune condition having a higher likelihood of resolution with appropriate treatment.

The symptoms of the autoimmune brain condition are some combination of the symptoms of psychosis listed above. A person with the autoimmune encephalitis may become disorganized, stop going to classes or work, socially isolate, stop attending to personal hygiene, talk to self, accuse people of being against them, believe others are out to get them, may become catatonic and withdrawn and become mute, or posture in strange ways. Their thoughts may be disorganized; they may be animated or agitated. The point is, there is a marked dysfunctional change from their normal behavior that is recognized by family and friends.

Clues that this may be autoimmune rather than schizophrenia include:

  • Quick onset in less than three months. If such changes have occurred gradually over years in a person who was odd, socially withdrawn, and peculiar since childhood, then it is more likely schizophrenia. But if the person experiences a fairly sudden and acute change in function, then the possibility of autoimmune encephalitis must be considered.
  • Recent history of infection, especially viral infection, prior to the onset of the dysfunction is a red flag warranting workup for autoimmune encephalitis. The underlying problem is that something (in this case, the viral infection) triggers the body’s immune system to make antibodies that attack the NMDA receptors in the brain, thereby causing the psychosis. Thus, a history of fever, malaise, headache, nausea, diarrhea, etc., prior to the onset of symptoms is a signal warranting investigation for an autoimmune cause.
  • Seizures within one year of the onset of the psychotic symptoms. These seizures are usually not the full-body seizures with loss of consciousness, but deep brain seizures that cause moments of confusion, staring off into space, or no symptoms at all and only show electrical slowing on an electroencephalogram (EEG). But seizures of any kind during the first year suggests an autoimmune problem.
  • A recent history of cancer or any abnormality of the ovaries suggests autoimmune encephalitis rather than schizophrenia. The cancer or ovarian problem, in this case, trigger the immune system to make the antibodies that attack the NMDA receptors.
  • A prior history of herpes simplex virus (HSV) encephalitis increases the risk of autoimmune encephalitis and, thus, any person presenting with psychosis who has a history of prior HSV encephalitis should be evaluated for an autoimmune cause of their psychosis. Again, the connection is that the prior herpes viral infection triggered the body to make antibodies that are now attacking the brain.
  • Any symptoms suggestive of a neurological problem, such as a stiff neck, severe headache, neck pain, etc., should raise concerns and justify an autoimmune workup.
  • Presenting with short-term memory loss may indicate an autoimmune cause to the new psychosis.
  • Changes and instability in normal vital signs, such as a racing heart, blood pressure that changes rapidly, and light headedness when standing, are indicators of an underlying autoimmune problem.

If someone you know is suffering with such symptoms, please bring up this possibility to their doctor as autoimmune encephalitis presenting as a psychotic disorder is a newly discovered insight and may not be considered by your loved-one’s doctor. The treatment for autoimmune encephalitis is quite different than that for schizophrenia, with a much higher likelihood of a good outcome.

 

 

 

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Testimony 67

I was introduced to Come And Reason by a friend of my mother-in-law, who gave me several CD’s of Dr. Jennings. The clarity of the message and recognition that God’s is a God of love was so clear, advancing beyond Dr. Maxwell’s message. However, grappled with Maxwell saying God used emergency measures for the fallen world. Now after several years of being a regular listener of the Come And Reasoning bible study class and attending Jennings’ meetings in Dallas/Fort Worth, TX, things are becoming clearer for me. Design law versus imposed law has added so much to my personal understanding of theology. This message has really impacted my work in counseling so many people miserable because they are searching for and trusting human governments to create order and peace or believing in a God who says love Me or I will kill you. I am grateful that I have an alternative view to offer my clients that makes sense. I teach a bible study class on a semi-regular basis and I value the materials that Come And Reason so freely offers to aid me in presenting this vital message. Thank you for continuing to provide advancement in our very limited understanding of a Infinite God that is rational and believable.

Dr. Roger D, Arlington, TX, USA

 

Testimony 46

Over the past couple of years God has been expanding my view of Himself and His character. Along my approximately 40-year journey, I have often had questions, but was hesitant to voice these and step outside the traditionally accepted thinking, for fear of admitting that I may in fact be eternally lost. In the recesses of my thinking has been the thought – if one blindly accepts (which is widely regarded as “real faith”) and does not question, is this really ‘truth?’ I often find it challenging to grapple with very theological ‘speak,’ but Dr. Jennings has a real gift of explaining spiritual concepts with clear practical examples. The weekly discussions are growing my Christian experience and slowly changing my view of how to live as a child of God in today’s complex world. Finally the whole Old Testament sanctuary teaching moved in my mind from fantasy to reality!

Beverly S., South Africa

 

Testimony 61

I grew up in a prominent protestant church and had what I like to call religious anxiety. I’ve always had questions about God and Salvation that no one could seem to answer.  I didn’t know how to find resolution. During 2020, at the height of my anxiety, I fell to my knees and begged God to show me truth and light and to give me the hope that I’ve been longing for. Days later, I stumbled upon your online videos and it was like a veil was lifted and EVERYTHING made sense! For the first time in my almost 39 years of life, my religious/spiritual anxiety has lessened. I feel a sense of freedom and peace I’ve NEVER had before… and it’s all because my view of God has changed. Thank you!

Ashleighn C.

 

Testimony 50

After coming into contact with Come And Reason Ministries, I can finally say that many of my unanswered questions have fallen into place. I discovered that my view of God’s Law was “imposed laws and rules” with “imposed punishments” and that this was the major culprit of my many unanswered questions. Thanks be to God for using you and those around you to help us who have struggled with this “infection” of thought. I have now rejected the “imposed law” concept to fully embrace “Design Law”… to look thru “Design Law,” instead of “imposed law,” is a relief.

Viliami L., Australia

 

Testimony 28

I have been following your Bible study class for about a year now. I must say I am impressed with how your ministry has grown. I took it upon myself to listen to all your lesson podcasts from the past and they have both enriched me physically, mentally, emotionally and spiritually. I have learnt a lot from this class. I have also noticed how the class has grown in spiritual strength. One of the things that benefited me is that now I am not afraid of God. I use to be, but now it has melted away. The second thing is that you helped me to have a real life relationship with God. Now He is my friend that was always there and I love having him with me all the time. Thirdly, because of this class, it inspired me to take over and lead a class. I have called it “Let Us Reason Together,” adapting your inquisitive style and creating a class of free thinkers.

T. Banda, Malawi, Africa

 

Testimony 54

I had a lot of pressure, as a pastor’s kid, to conform and be “good.” I was good at being “good.” I thought my life was going along well until it all started falling apart and I could not figure out why! In my search for “why is this happening to me, God?” I came across your book, “Could it be this Simple,” and God started revealing to me the many distortions I held about His character, His principles, and how He has designed His universe to operate. I remember thinking, “Wow, I have had this all backwards.” I was happy and angry all at the same time. Happy to have the light of truth break through the darkness, revealing a wonderful, beautiful way of understanding God and His plan for His children, and angry, because I felt deceived and cheated by the church, my family, and myself!

My heart thrills when I listen to your bible study lessons. Literally I have gone from death to life. It is a journey I look forward to every day, as God reveals areas this distortion affects. Praise GOD! I will ever be grateful to God for this ministry and your cooperation with the Spirit!

Karen S., Portal, AZ, USA

 

Testimony 45

I have been confused for years about what [christianity] calls [its] most disgusting teaching. It has never made much sense to me and for that reason has been evermore empty. I have listened to your class off and on and have struggled determining what is truth, because of the resistance design law encounters in the church. So, I thank God for your ministry. What you teach makes sense. It’s logical and backed up by the power of love. I have never seen that in Christ until now. I am astounded by the insight that is found when we look at God’s ministry through design law. All strength to this message, as I believe it to be the power of God.

Brendon S.

 

Testimony 35

I am so pleased with the response your message is receiving at my church from the middle-aged to the young adults. I have given out 100 copies of the first two seminars and there are more request every week. One of my [class members] came to me after viewing the series, grateful and impressed with how easy the message was retained. He had been a Seventh-day Adventist in fear all his life, and felt like the scales were removed from his eyes after viewing the seminars. I am so impressed by the change I see in members who have received this message, we are in one accord. However, I am sadden by the negative response of the older people. I am verbally attacked anytime I talk about imposed laws, but I believe my mission is to enlightened everyone I can. I watch your Bible Study Class on YouTube every Friday night and I feel like I am apart of the class. All of you are in one accord and I am so blessed to have found you. I pray that all of you continue to spread this message and I am committed to doing my part.

Clara S., Westfield, MA, USA

 

Testimony 11

I would love to have a copy of “Healing the Mind” DVDs to have in my therapy office. I enjoy having clients check out materials to enhance their therapy experience. I have sat under Dr. Jennings’ teaching at an American Association of Christian Counselors convention and respect his work greatly.

K.B., LA, USA

 

Testimony 66

I am incredibly grateful for the transformative impact you’ve had on my life, and words cannot fully express my appreciation. Over the years, I have been an avid listener and follower of C&R and extend my heartfelt thanks for creating the C&R mobile app. It has allowed me to immerse myself in your lessons repeatedly, enabling me to grasp the profound significance about the Character of God, Design Law, the protocols for life, the reasons behind the current chaos, and Christ’s mission to restore everything. They have deeply touched me. Having studied with various churches, I came away with the perception that God is no different from the deities of ancient Greek or Roman mythology—demanding sacrifices and taking pleasure in bloodshed. Thanks to your transformative teachings, I have experienced a profound awakening to the true nature of God and the immense power of His love. It is truly a remarkable and liberating sensation to finally grasp the truth and embrace the empowering nature of God’s laws. My self-perception has become brighter and more infused with love. My journey of growth continues on a daily basis.

Chris P., Lake Mary, FL, USA

 

Testimony 53

I was so blessed by a friend who gave me your book, “The God Shaped Brain,” while I was sitting in church asking God to please help me learn more about Him and help me not to be so confused and scared. That was about 2 years ago. Your books have helped me to love God even more. I’m not confused or scared anymore! I have listened to all of your bible study classes and feel like I know the wonderful people that attend every week. Thank you for all that you’re doing in spreading the true message about God and His law of love. God bless you and your whole class.

Elssy P., Modesto, CA, USA

 

Testimony 49

I came into the church at 21, but that is as far as it went. I was so confused about what love is. I couldn’t find it in the bible, because I am not a person that can read between the lines. I have no logic. I have read many, many books; trying to figure out the crux of the matter. They were helpful, but something was still missing. I have become very frustrated to the point of crying out to God, “Where can I go?”  I needed some basics.

I found two books, written by Timothy Jennings, MD, to be very helpful. God showed me that I had lived my whole life in fear. I didn’t even see it. Now, I do. God is so good.  I discovered the “The Remedy”  Dr. Jennings new book, “The God-Shaped Heart!” Oh, I was so excited, I purchased them right away.

I can get rid of most of my books, because “The Remedy” brings the Love of God out so clearly, even I can’t miss it. Now, I want to sit and read my Bible. Wow, what a revelation! It is just simply Awesome! I am so grateful to Jehovah Almighty for hearing my prayer for more understanding! I am so encouraged!

Jackie S.

 

Testimony 32

The message [of Come And Reason Ministries is] for all Christians (and those who may become Christians) and not just Adventists or any other group. It is difficult to imagine why any [anyone] with intellectual and spiritual honesty could find fault with the way you explained the healing substitution concepts and the truth about God’s character, though I know some will reject and criticize. On behalf of those in our group near Tacoma, WA, thank you and your staff for all of the hard work and for sharing the Gospel in this manner. God’s message of healing love will be carried to the whole world and then Jesus will come – He promised it.

Terry U., Tacoma, WA, USA

 

Testimony 70

I have been watching you for many years and have learned to love God with all my heart. I was raised by a loving Christian mother that had been lied to about who God really was, so our religious upbringing was hell fire and damnation. As soon as I was old enough and moved out, I not only left the church, I ran as fast as I could to get away from it. Sad to say, it wasn’t until the past couple of years that I learned and understand who my Father really is and how much He loves me. I understand God’s Design Laws (which make sense) and when I’m teaching my church Bible study class, I’m able to really put to use the things I’ve been learning and Holy Spirit is leading. Thank you for introducing me to my Father of true, pure love. Everyday with Him is new and exciting. One thing that breaks my heart is that I didn’t know Him sooner. God Bless you and your ministry!

Judy Phelps, Reno, NV, USA

Testimony 52

Your unique way in spreading the truth is what we all need today. Most of us don’t recognize the contamination coming from all the lies and selfishness in the world. Because of our fear of death, we forgot how to live. Lies left and right. I was losing hope and faith, because of so many ideas that are always contradicting each other – so many questions answered by other, more complicated, questions – until I found your channel on YouTube.

You did not just give me answers, you also taught me how to answer new questions that arise in my mind. Now I see things differently. I see God’s mercy, grace, and Love everywhere, in spite of all the chaos that we all have done as humans. I don’t fear death anymore. Accepting the Truth and Love about God is truly a genuine Freedom from all the confusions, sufferings, selfishness, pain, and death.

I just wanted to say, thank you, sooooo much for revealing the real Remedy for our infected life. I have a new hope and now see the world in a different perspective!

Wheinny P., University Place, WA, USA