Call Us: 423 661-4734 | Email: requests@comeandreason.com      
Psychosis, Schizophrenia, or Autoimmune Brain Inflammation—New Hope for Some

Psychosis, Schizophrenia, or Autoimmune Brain Inflammation—New Hope for Some

One of the most distressing things a person can go through is a break in their touch with reality—psychosis—whether in themselves or in a loved one. Psychosis is a term for no longer being able to tell what is real from what is not. The various types of psychotic symptoms include:

  • Hallucinations: These are disturbances in perception—perceiving sensory signals that are not coming from the world around us. The most common is auditory hallucination, hearing things without actual sound waves impacting the ear drums, but people can also see, smell, feel, and taste things that are not coming from their environment.
  • Delusions: These are fixed false beliefs—believing things that are objectively contrary to reality; delusional beliefs are not amenable to being changed with evidence and facts.
  • Disorganization of thought and speech: The inability to maintain a clear train of thought; jumping from topic to topic in a nonsensical way.
  • Disorganization of behavior: Gross irrational and chaotic behavior.
  • Catatonia: A severe and abnormal response to people and the environment, such as mutism, echoing sounds repeatedly, copying other’s movements constantly, rigidly holding positions for long periods of time, failure to respond to environmental stimuli, and other symptoms.
  • Severe loss of normal emotional connection: Severe emotional flatness; loss of motivation, disengagement, and isolation.

It has been long understood that psychotic problems are a result of something going wrong with normal brain function. The only exception are shared delusions, when people come to believe something that is false and are resistant to evidence that would expose the falsehood. Shared or group delusions come from social and relational pressures and not brain dysfunction. So, delusions can occur from both brain dysfunction and from social and relational pressures and stresses.

Historically, when a person presented with the various symptoms listed above, they were recognized as having a break from reality and diagnosed with psychosis. If the symptoms persisted over time, they were often diagnosed with schizophrenia.

The exact causes of schizophrenia are still poorly understood, but it is believed to have multiple causes related to brain development, structure, and function. Genetics play a role, increasing vulnerability, but genes do not tell the entire story. Intrauterine environment, toxic exposures, infections, nutritional deficiencies, and environmental stressors all impact the developing brain and can alter normal cellular development, support systems, and connectivity and, thereby, contribute to the development of psychosis later in life. The point is that every person diagnosed with schizophrenia does not have the exact same brain problem; they share a cluster of symptoms that are used to diagnose schizophrenia. But it is currently believed that there are many different underlying contributing factors and brain changes that lead to these symptoms.

 

New Discoveries

What is interesting is that recently, a condition has been discovered that shares the symptoms of schizophrenia and historically would have been diagnosed as schizophrenia but, in fact, is an autoimmune inflammation of the brain. In other words, the body has made antibodies that are acting inappropriately upon certain brain receptors (NMDA) and causing the symptoms of psychosis.

Recently I read an article entitled “Is it psychosis, or an autoimmune encephalitis?” in which the differences between psychosis and this brain inflammatory condition were described. This is important and exciting because the presentations of both these conditions are nearly identical while the underlying causes are quite distinct and the treatments are necessarily different, with the autoimmune condition having a higher likelihood of resolution with appropriate treatment.

The symptoms of the autoimmune brain condition are some combination of the symptoms of psychosis listed above. A person with the autoimmune encephalitis may become disorganized, stop going to classes or work, socially isolate, stop attending to personal hygiene, talk to self, accuse people of being against them, believe others are out to get them, may become catatonic and withdrawn and become mute, or posture in strange ways. Their thoughts may be disorganized; they may be animated or agitated. The point is, there is a marked dysfunctional change from their normal behavior that is recognized by family and friends.

Clues that this may be autoimmune rather than schizophrenia include:

  • Quick onset in less than three months. If such changes have occurred gradually over years in a person who was odd, socially withdrawn, and peculiar since childhood, then it is more likely schizophrenia. But if the person experiences a fairly sudden and acute change in function, then the possibility of autoimmune encephalitis must be considered.
  • Recent history of infection, especially viral infection, prior to the onset of the dysfunction is a red flag warranting workup for autoimmune encephalitis. The underlying problem is that something (in this case, the viral infection) triggers the body’s immune system to make antibodies that attack the NMDA receptors in the brain, thereby causing the psychosis. Thus, a history of fever, malaise, headache, nausea, diarrhea, etc., prior to the onset of symptoms is a signal warranting investigation for an autoimmune cause.
  • Seizures within one year of the onset of the psychotic symptoms. These seizures are usually not the full-body seizures with loss of consciousness, but deep brain seizures that cause moments of confusion, staring off into space, or no symptoms at all and only show electrical slowing on an electroencephalogram (EEG). But seizures of any kind during the first year suggests an autoimmune problem.
  • A recent history of cancer or any abnormality of the ovaries suggests autoimmune encephalitis rather than schizophrenia. The cancer or ovarian problem, in this case, trigger the immune system to make the antibodies that attack the NMDA receptors.
  • A prior history of herpes simplex virus (HSV) encephalitis increases the risk of autoimmune encephalitis and, thus, any person presenting with psychosis who has a history of prior HSV encephalitis should be evaluated for an autoimmune cause of their psychosis. Again, the connection is that the prior herpes viral infection triggered the body to make antibodies that are now attacking the brain.
  • Any symptoms suggestive of a neurological problem, such as a stiff neck, severe headache, neck pain, etc., should raise concerns and justify an autoimmune workup.
  • Presenting with short-term memory loss may indicate an autoimmune cause to the new psychosis.
  • Changes and instability in normal vital signs, such as a racing heart, blood pressure that changes rapidly, and light headedness when standing, are indicators of an underlying autoimmune problem.

If someone you know is suffering with such symptoms, please bring up this possibility to their doctor as autoimmune encephalitis presenting as a psychotic disorder is a newly discovered insight and may not be considered by your loved-one’s doctor. The treatment for autoimmune encephalitis is quite different than that for schizophrenia, with a much higher likelihood of a good outcome.

 

 

 

Email me the blog whenever a new one is published.

Donate online, securely via PayPal using your credit or debit card (no PayPal account needed, unless you want to set up a monthly, recurring payment).


cancel recurring payment

 

Want to use zelle instead?
See how on our
Support and Donations page.

Upcoming Events

calendar

Testimonial Post Slider

Testimony 31

It was very touching to hear the testimony of your class share how viewing God’s true character has changed their lives. My feelings are the same – there is so much freedom in knowing that God LOVES me – regardless of my… just, REGARDLESS! I’m still blown away by the true gospel, the fact that God is not ready to strike us when we fail. He is not arbitrary. He simply loves us and warns of the natural consequences because He can’t stand to see us suffer. I AM IN LOVE WITH THIS GOD!!!

Ceil V.,  UT, USA

 

Testimony 69

After reading your book, ‘Could It Be This Simple,’ someone was explaining Christianity in a way that made sense to me for the first time in my life. One morning, I simply prayed “I’m sorry and I love you.” As soon as I silently said that, I could literally feel God’s presence and light flood down on me from above and fill me up with love and joy. I sat there crying my eyes out, because I was so overpowered with this feeling of love and joy. It was just so incredible. I hope that more people can read this book and get a blessing from it. It’s really amazing.

Rachael H.

Testimony 76

Warm greetings from Tanzania! I just wanted to take a moment to thank you and your team at Come And Reason Ministries for the amazing work you do. Your teachings have opened my eyes to deep biblical truths and how to live them out in real life. I started following the ministry back in 2018, and ever since, my walk with God has grown so much stronger. I’ve found freedom from fear-based faith and now live with more peace and trust in Him. I’ve also been sharing what I’ve learned, especially through Bible School discussions. Your lessons are so insightful and well-explained that I try not to miss a single one. May God continue to bless the work you’re doing.
Elisha M., Tanzania, Africa

Testimony 54

I had a lot of pressure, as a pastor’s kid, to conform and be “good.” I was good at being “good.” I thought my life was going along well until it all started falling apart and I could not figure out why! In my search for “why is this happening to me, God?” I came across your book, “Could it be this Simple,” and God started revealing to me the many distortions I held about His character, His principles, and how He has designed His universe to operate. I remember thinking, “Wow, I have had this all backwards.” I was happy and angry all at the same time. Happy to have the light of truth break through the darkness, revealing a wonderful, beautiful way of understanding God and His plan for His children, and angry, because I felt deceived and cheated by the church, my family, and myself!

My heart thrills when I listen to your bible study lessons. Literally I have gone from death to life. It is a journey I look forward to every day, as God reveals areas this distortion affects. Praise GOD! I will ever be grateful to God for this ministry and your cooperation with the Spirit!

Karen S., Portal, AZ, USA

 

Testimony 46

Over the past couple of years God has been expanding my view of Himself and His character. Along my approximately 40-year journey, I have often had questions, but was hesitant to voice these and step outside the traditionally accepted thinking, for fear of admitting that I may in fact be eternally lost. In the recesses of my thinking has been the thought – if one blindly accepts (which is widely regarded as “real faith”) and does not question, is this really ‘truth?’ I often find it challenging to grapple with very theological ‘speak,’ but Dr. Jennings has a real gift of explaining spiritual concepts with clear practical examples. The weekly discussions are growing my Christian experience and slowly changing my view of how to live as a child of God in today’s complex world. Finally the whole Old Testament sanctuary teaching moved in my mind from fantasy to reality!

Beverly S., South Africa

 

Testimony 20

I just wanted to personally thank you for your teachings and insight into scripture. I came across your website via my cousin who suggested I look into “Healing the Mind” information. My youngest daughter has been struggling over the last couple of years and it all came to a head this spring. When I started listening to the “Healing the Mind” lectures my own life began to be transformed. I began sharing with all my daughters the concepts you laid out so clearly. I ordered your book and soaked it up. I just want to say “Thank You!” My walk with the Lord has been refreshed and renewed. Your obedience to the Lord is a blessing to so many.

R. K., Anderson, SC, USA

 

Testimony 27

Your teachings about our heavenly Father have changed my life. Thank you sooooooo very very much! I know He’s doing some serious healing in my heart and life and I look forward to each new day to learn something new about Him and to just hear you speak about Him. Thank you, forever.

Nancy S.

 

Testimony 14

We really appreciate your views on the judgment and they make good sense considering our free choice.

Anonymous

 

Testimony 64

I’ve been reading the bible and walking with Jesus since I was around 16. I’m 42 now. I’ve mostly been alone in my walk although I went to several churches in different denominations. For the past 3 years God has been showing me His character of agape. It’s been a blessing and changed how I view God and my walk with Jesus. About a year ago I came across the power of love and the principles of design law. These teachings changed how I read scripture and have been such a beautiful blessing. I’m very excited and grateful for these truths. We share these truths of agape, design law and the reality of the principles of the two trees in the garden of Eden with people on Facebook and YouTube. People all over are learning to trust God and His agape design law which makes life possible. Thank you for everything you shared with me. May God continue to bless your ministry and lives.

Bradley M., Hinsdale, NY, USA

 

Testimony 13

I borrowed “Healing The Mind” DVDs from a friend and showed them at my home for a small gathering of women friends. Neither of my friends are Adventist, but they both enjoyed and embraced the messages you taught. In fact, one of the ladies prayed out loud in our group and that was the first time she had ever had public prayer.

J.B. ,Dalles, OR, USA

 

Testimony 21

I am absolutly on fire with the message at Come and Reason! I can’t get enough! I’ve read your book, blog, and articles. I’ve listened to your Bible study podcasts, your radio show, and your series – all excellent! It wasn’t until the past couple of years that I have I like I’m becoming “healthy,” with more to share with others than just beasts and commandments! I used to be a Bible worker and preached when the pastors were gone until I had had enough. I didnt realize at the time what the problem was, but i know now… the message wasn’t properly focused. Now my flame is rekindled. All of your little examples are so perfect in explaining something “complicated” and making it easily understood! Now I’m trying to shape it into a life changing evangelistic series! Thank you!

M.T., USA

 

Testimony 34

I was introduced to Come and Reason Ministries by accident, via a passing comment made in a bible study class we were visiting. I checked this website out and my life was changed. The understanding of the truth of God’s character, and how we apply it, is so right. The tricky part is consistently applying which “lens” to look through. As I began to understand, I started sharing the basics of this understanding with a discussion group I was leading and, suddenly, a lot of things started to make sense that never used to. At the same time, I enjoyed an amazing opportunity. I was able to conduct a full bible study at WORK! What an amazing experience! It is such a joy to share the truth about God and to share how it all fits in the war between God and Satan. So many people benefit when we have a correct understanding about how God works and who He really is! Thank you for this transformational understanding. Keep up the good work! God Bless you!

Tony P., CA, USA

 

Testimony 42

I am just writing to say that I have been so blessed by the teachings of Come And Reason Minitries recently. I watched last week’s bible study lesson on Youtube and am thankful that the error in the printed lesson guide you use was pointed out and this week’s study was of equal benefit, if not more so. My understanding of God’s nature has been very confused of late and I am so grateful for clarity in this matter. I have never really fully understood previously how a good God can cause bad things to happen and now I realise that He doesn’t, it’s a natural consequence of sin. May the almighty Father and His Son, our Saviour Jesus Christ, continue to bless your ministry.

Laura P., United Kingdom

 

Testimony 72

I am blown away by the truth that you present. God’s Design Law makes so much sense! You have validated my impression that, if God is love, He would not kill those who don’t want to know him. If God gives us choice, then how can He destroy us if our choice is not to follow him. Thank you for opening my eyes and heart to the pure love of God seen through Jesus. The love I now have for Jesus is deeper and free from condemnation. My heart has been opened to love others as Jesus loves me. May God continue to bless your God-given insight into His word and your ministry. The truth has set me free!

H. Miller, Centereach, NY

Testimony 15

I have been sharing Come And Reason Ministries Bible study lessons with several folk. You have such a beautiful view of the plan of salvation. If we had this message preached when I was young, my generation would still all be in church.

H. R., New Zealand